Abstract

REVIEW ARTICLE:- ANTIOXIDANT AND ANTIDIABETIC ACTIVITY OF ZIZIPHUS OENOPLIA LEAVES EXTRACT ON ALLOXANINDUCED DIABETIES IN RATS

Krishnapal Nagda*, Dr. Jai Singh Vaghela

Abstract

This review synthesizes current evidence on the antidiabetic and antioxidant potential of Ziziphus oenoplia (Jackal Jujube), a plant traditionally used in herbal medicine. Preclinical studies, primarily in alloxan- and streptozotocin-induced diabetic rat models, demonstrate its ability to lower blood glucose and improve lipid profiles. The antidiabetic effects are attributed to inhibition of carbohydratehydrolyzing enzymes α-amylase and α-glucosidase, with inhibitory potency comparable to standard drugs like acarbose. Molecular docking studies identify quantic acid as a key bioactive compound. Antioxidant assays reveal strong free radical scavenging activity, with IC₅₀ values close to that of ascorbic acid, supporting its role in mitigating oxidative stress linked to diabetic complications. Acute toxicity studies confirm safety at high doses. The dual actions-glycemic control and oxidative stress reduction— position Ziziphus oenoplia as a promising candidate for natural diabetes therapeutics. Future research should isolate active constituents, evaluate their effects on oxidative stress biomarkers, and validate efficacy in human clinical trials.

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