Abstract

A REVIEW ON SOLID LIPID NANOPARTICLES

T. Mathesvaran*, Dr. S.K. Senthilkumar, S. Nisma, N. Pavithra, K. Pooja, J. Potriselvan, R. Praveenkumar

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Abstract

Solid lipid nanoparticles are stable colloidal carriers made of lipids solid at both room and body temperatures .They are formed of a solid lipid core stabilized by a surfactant and containing the drug dissolved or dispersed. They consist of macromolecular materials in which the active component is dissolved, entrapped, or in which the active component is adsorbed or attached .They have been used as a physical approach to alter and improve the pharmacokinetics and pharmacodynamic properties of a various types of drug molecules. The review highlights the most widely used methods for synthesis of SLNs including Solvent emulsification evaporation, Solvent emulsification diffusion, solvent injection, High pressure homogenization, Phase inversion temperature, High speed stirring and ultra sonification, Membrane contactor, Micro emulsion, Co-acervation, Double emulsion and super critical fluid. Each method offers unique advantages interms of particles size control, surface modification, drug loading efficiency and targeted delivery. The application of SLNs acrossed drug delivery systems for controlled release, targeted delivery, gene therapy. Additionally SLNs have significant potential in treatment of cancer, Tuberculosis, Parasitic diseases like malaria and leishmaniasis, due to their ability to improve therapeutic efficacy with targeted delivery while minimizing side effects. In this review the different techniques for preparation of the SLNs are described and also contains its characterization, route of administration and application.

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