Abstract

A REVIEW ON ORAL DISINTEGRATING TABLETS AND ORAL SOLUBLE FILMS

Arjumand Afreen*, Sowjanya Battu, Akhila Alladi, Dr. V. Uma Maheshwara Rao

Abstract

Oral drug delivery is the most prominent route of adminstation,Fast disintegrating tablets and fast dissolving filims are gaining importance now a days due to their rapid and effective drug release.Fast disintegrating tablets avoids some prolems like pediatric and geriatric patients, have difficulty swallowing or chewing solid dosage forms. Many pediatric and geriatric patients are unwilling to take these solid preparations due to fear of choking. For example, a very elderly patient may not be able to swallow a daily dose of antidepressant in the form of a Caplet shaped Tablet. Orally disintegrating tablets (ODTs) are a perfect fit for all of these patients. Fast-dissolving drug delivery systems have rapidly gained acceptance as an important new way of administering drugs. There have also been significant increases in the number of new chemical entities under development using a fast-dissolving drug delivery technology. Mouth dissolving film becomes a novel approach to oral drug delivery system as it provides convenience and ease of use over other dosage forms such as orally disintegrating tablets buccal tablets and sublingual tablets, so mouth dissolving films are gaining the interest of large number of pharmaceutical industries. Mouth dissolving film was developed on the basis of technology of transdermal patch. Mouth dissolving films are thin solid dosage forms which when placed in the oral cavity; dissolve within few seconds without chewing and intake of water. The oral buccal mucosa being highly vascularized, drugs can absorbed directly and can enter the systemic circulation without undergoing first-pass hepatic metabolism. This advantage can be exploited in preparing products with improved oral bioavailability of molecules that undergo first pass effect. These films offer convenient way of dosing medication to pediatric, geriatric and bedridden patients. Present review provides an account of various formulation methods and their evaluation used in film formulations and applications of Fast dissolving tablets and Oral soluble filims.

Keywords: Oral disintegrating tablets, Oral soluble filims, Preperation techniques, Applications.