Abstract

SYNTHESIS AND EVALUATION OF A SERIES OF 3-[4-(1- (PHENYLSULFONYL)-5-(SUBSTITUTED PHENYL)-4,5-DIHYDROPYRAZOL- 3-YL)PHENYL]-6,8-DIBROMO-2-METHYLQUINAZOLIN- 4-ONE AS AN ANTIMICROBIAL AGENTS

Dr. Komal Savaliya*

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Abstract

In the present study a new class of substituted Pyrazole derivatives containing Quinoline moiety 2a-2j have been designed and synthesized by the reaction between 6,8-dibromo-3-{4-[5-(substitutedphenyl)-4,5- dihydro-pyrazol-3-yl]phenyl}-2-methyl quinazolin-4-one (1a-1j) with benzene sulphonyl chloride by using pyridine as a solvent. 1a-1j intermediate have been synthesized by the cyclization of 6, 8-dibromo- 3-{4-[3-(substitutedphenyl) prop-2-enoyl]phenyl}-2-methylquinazolin- 4-one with 99% hydrazine hydrate by using ethanol as a solvent. The newly synthesized compounds were screened for their antibacterial and antifungal activities by Agar Cup method. Several of these novel compounds showed good antibacterial and antifungal activity than standard drugs like Streptomycin and Fluconazole respectively. The chemical structures of newly synthesized sulphonyl pyrazoline derivatives were characterized on the basis of IR, NMR and spectral data as well as physical data.

Keywords: Sulphonyl pyrazole, synthesis, Antibacterial activity, Antifungal activity.