Abstract

ANTI-INFLAMMATORY POTENTIAL OF A TOTAL AQUEOUS EXTRACT OF THE STEM BARK OF SACOGLOTTIS GABONENSIS BAILLE URBAN (HUMIRIACEAE) IN WISTAR RAT

Ousmane Nagalo*, Djè Kouamé Wenceslas Kouame, Behiblo N'Guessan Bah Konan, Mama Kone

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Abstract

Sacoglottis gabonensis, a medicinal plant belonging to the Humiriaceae family, is used for the treatment of Buruli ulcer in Côte d’Ivoire. It has been the subject of several pharmacological and toxicological studies. The objective of this study is to verify the acute anti-inflammatory effect of the total aqueous extract of the stem bark Sacoglottis gabonensis (TAESg) in Wistar rat. For this purpose, 36 rats were divided into six homogeneous groups of six rats. Group 1, negative control, received distilled water; group 2, positive control, received aspirin® at a dose of 100 mg/kg bw; groups 3, 4 and 5 received TAESg at respective doses of 3.5; 17.5; 35 and 350 mg/kg bw for preventive anti-inflammatory activity. One hour after oral administration of TAESg, each rat received by injection under the plantar pad of the right hind paw 0.1 mL of fresh egg albumin or 0.1 mL of the 1% carrageenan solution depending on the test carried out. For curative anti-inflammatory activity, one hour before after administration of the different substances orally, each rat received, by injection under the plantar pad of the right hind paw, either 0.1 mL of 1% carrageenan solution; either 0.1 mL of fresh egg albumin. In order to assess the evolution of the plantar edema caused by this injection, a measurement of the right hind paw of all rats was carried out 1 hour; 2 hours; 3 hours; 4 and 5 hours after injection. This study showed that TAESg at different doses significantly reduced the edema induced by fresh egg albumin and carrageenan during the preventive and curative studies in this experiment. Ultimately, TAESg has acute preventive and curative anti-inflammatory activity. However, more in-depth studies of this extract must be carried out on the analgesic and antipyretic power.

Keywords: Sacoglottis gabonensis, Buruli ulcer, anti-inflammatory activity, rat.