Abstract

FORMULATION AND EVALUATION OF SUBLINGUAL FILMS OF AMPHETAMINE SULFATE

Kush Kumar Patel, Priyanka Yadav*, Jaini K. Patel, Disha Suthar, Aradhana Patel, Jaymina G. Panthaki

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Abstract

The present work was attempted to formulate and evaluate sublingual films of Amphetamine sulfate. Literature survey was carried out for selection of suitable excipients. Preformulation studies were conducted to identify Amphetamine sulfate by means of UV Spectrophotometric test and melting point determination. The results of compatibility studies were carried out by FTIR. The result of FTIR analysis showed compatibility without any significant interaction. Preliminary studies were conducted with an attempt to select suitable polymer and to see the effects of it on in- vitro disintegration time, % release of drug and mechanical properties like folding endurance, tensile strength etc. Polymer except Pullulan gives more thickness and requires more time to disintegrate and dissolved. So, it requires more time to give maximum drug release. From the results of preliminary studies, Pullulan was selected to optimize the rapidly disintegrating film and gives fast drug release. It gives more than 90% drug release in 10 min and 21 sec Disintegration time.

Keywords: Amphetamine sulfate, Pullulan, PEG 400, Sublingual Films.