Abstract

EFFECTS OF DIFFERENT DOSES OF POTASSIUM DICHROMATE ON MALE FERTILITY AND LIVER TISSUE IN PREPUBERTAL RATS

Merza H. Homady*, Khawaja Shakeel Ahmed, Mirzan M. Omer

.

Abstract

Chromium is a naturally occurring heavy metal, and its hexavalent form (Cr (VI)) is particularly toxic. Potassium dichromate (K₂Cr₂O₇) is one of the most commonly used Cr (VI) compounds in various industries, posing serious environmental risks. The toxicological consequences of acute exposure to varying doses of potassium dichromate were examined in male rats. Following six weeks, fertilityrelated experiments were conducted to evaluate both testicular and liver changes, biochemical alterations, and reproductive parameters. Histological sections were further analyzed to assess the influence of potassium dichromate on lipid profiles, liver enzyme activities, and reproductive functions. The present findings revealed marked adverse effects on male reproductive health, including reduced fertility and structural alterations in testicular and liver tissues across the tested dose levels. These outcomes suggest that hexavalent chromium compounds may play a contributing role in the global rise of male infertility. Thus, when addressing challenges related to male reproductive health, environmental factors such as exposure to potassium dichromate must be taken seriously into consideration.

Keywords: Potassium Dichromate, Rat, Testes, Fertility, Lipid.