Abstract

A REVIEW: DECODING DEPRESSION- CLINICAL INSIGHTS AND FUTURE DIRECTIONS

Yashvi Paghadal, Riti Pansuriya, Heer Patel, Vishva Vyas, Janki Patel*

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Abstract

Depression is a common, debilitating mood disorder marked by persistent feelings of sadness, loss of interest or pleasure (anhedonia), and a range of cognitive, emotional, behavioral, and physical symptoms. This review examines the current understanding of psychological, and social, and clinically significant signs and symptoms. We also explore treatment modalities—psychotherapy, pharmacotherapy, and emerging interventions—as well as challenges in diagnosis (such as subthreshold and atypical forms), comorbidity, and relapse prevention. Despite advances in treatment, many individuals do not receive adequate care, due to stigma, access barriers, or heterogeneity in symptom presentation. Improved diagnostic tools, personalized treatment strategies, and public health initiatives are needed to enhance outcomes and reduce the global burden of depression. This study suggests that happy mood, sad mood, and negative ways of thinking often start to improve around the same time during treatment of depression. Fewer improvements were found in activities and interactions, which explains why activities and interactions often improved after individuals started to feel better.

Keywords: Depression, Mood disorder, Anhedonia, Pharmacotherapy, Psychotherapy.