Abstract

STUDY OF THE HEPATOPROTECTIVE POTENTIAL OF AQUEOUS AND HYDROETHANOLIC EXTRACTS OF PAVETTA CORYMBOSA (DC) F.M. WILLIAMS (RUBIACEAE) LEAVES

Miezan Bilé Aka Patrice*, Kouamé Yao Yves, Yao N’guessan Alain Roland

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Abstract

As part of the promotion of traditional medicine, a pharmacological study was conducted on aqueous and hydroethanolic extracts of Pavetta corymbosa leaves, a plant used in traditional medicine. The study focused on evaluating the hepatoprotective potential of these two types of extracts. As part of this evaluation, rats whose livers had been poisoned by carbon tetrachloride (5 ml/kg bw) were treated with aqueous and hydroethanolic extracts of Pavetta corymbosa leaves at a dose of 200 mg/kg bw and silymarin, a hepatoprotective drug, at a dose of 100 mg/kg bw. This study shows that the hydroethanolic extract and silymarin significantly (p < 0.05) reduce hepatoxicity in rats compared to the aqueous extract. This effectiveness of the hydroethanolic extract could be explained by the presence of saponosides and quinones present in the said extract compared to the aqueous extract. The effectiveness of the hydroethanolic extract of Pavetta corymbosa leaves similar to reference drugs for the treatment of hepatoxicity could be a hope for traditional medicine.

Keywords: Aqueous extract, hydroethanolic extract, Pavetta corymbosa, hepatoprotective.