Abstract

PREPARATION AND EVALUATION OF ISONIAZID SOLID LIPID NANO PARTICLES

Radha Gadela* and Sravan Kumar Moka

Abstract

Nanoparticulate drug delivery has been a considerable research interest in the area of drug delivery using particulate delivery systems as carriers for biologically active agents. They show a wide range of possibilities to obtain desirable drug properties by altering or converting the biopharmaceutical and pharmacokinetic properties of the molecule. Isoniazid is first line medication in the prevention and treatment of tuberculosis. In the following laboratory studies solid lipid Isoniazid nanoparticles were prepared using Stearic acid and Tween 20 by w/o/w double emulsion-solvent evaporation method. The isoniazid nanoparticles were characterized by using Scanning electron microscopy(SEM), particle size distribution by Zeta sizer. The nanoparticles were evaluated for their drug loading efficiency, drug diffusion. The prepared SLNs were found in spherical shape. Present Work is focused on increase incorporation of drug into SLN. Work indicates that SLN of isoniazid can give reliable therapeutic effect for the treatment of tuberculosis by prolonging its action.

Keywords: Solid Lipid Nanoparticles, Isoniazid, Tween20, Stearic acid.