Abstract

PROLIPOSOME: NOVEL DRUG DELIVERY SYSTEM

Gitanjali Parmar*, Rajni Bala, Nimrata Seth, Dr. Angshu Banerjee

Abstract

Liposome are biologically inert microscopic vesicles in which aqueous compartment is enclosed by a lipid bilayer membrane. Liposomes are most promising and broadly applicable drug delivery system. But liposomes are associated with poor stability problem and this leads to be storage problem .To overcome the stability problem proliposomes were discovered by Payne et al. in 1986.Proliposomes are defined as dry, free flowing particles with a dispersed system that can immediately form a liposomal suspension when in contact with water. Proliposome are helped to improve the bioavailability. This paper reviews the method of preparation, merits, evaluation of Proliposomes and highlights its potential to be exploited for different routes of administration.

Keywords: Liposome, Proliposomes, Carriers, Phospholipids and Cholesterol and multilamellar.