Abstract

ANTI-INFLAMMATORY ACTIVITY AND FTIR ANALYSIS ON THE ETHANOLIC EXTRACT OF MUSA SAPIENTUM ON EXPERIMENTAL PEPTIC ULCERS IN RATS

*C.Sumathy and 2Dr.N.Vijayakuma

Abstract

Banana belongs to the family of Musaceae. Ethanolic Extract of unripe Musa sapientum(EEMS) was subjected to FTIR(Fourier transform infrared spectrophotometer) analysis and anti-inflammatory activity. The anti-inflammatory activity of EEMS was evaluated using Carrageenan-induced rat paw oedema,Formalin induced rat paw oedema and Cotton pellet granuloma test at doses of 100,200,400 and 600mg/kg bw. Carrageenan is widely used to induce acute inflammation and it is a suitable test for determining anti-inflammatory action of drugs and have been used to assess the anti-oedematous effect of natural products. Formalin causes peripheral tissue inflammation. The cotton pellet model is an indication for the proliferative phase of inflammation.In the present study,EEMS showed the presence of various functional groups present and significant dose dependent antiinflammatory effect in both Formalin-induced rat paw oedema and Cotton pellet granuloma model.

Keywords: Carrageenan,Formalin,oedema,cotton-pellet,granuloma,anti-inflammatory.