Abstract

FORMULATION AND EVALUATION OF BREXPIPRAZOLE IMMEDIATE RELEASE TABLETS

Tirumala Devi Kolli*, Shaik Roshan Babu, Prasada Rao Manchineni

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Abstract

Objective: The aim and objectives of the present study is to develop a pharmaceutically stable, cost effective and quality improved formulation of Brexpiprazole immediate release tablets. Materials and Methods: The Brexpiprazole immediate release tablets are prepared by the wet granulation method, employing several polymer combinations, Brexpiprazole immediate release tablets were formulated by using microcrystalline cellulose (diluent), Sodium starch glycolate (super disintegrate), Povidone K 30 (binder) and magnesium stearate (lubricant) and Aerosil 200 pharma (carrier/glidant). Individual drugs and polymers and their physical mixtures were investigated by FTIR. Results: The formulation was subjected to pre-compression analysis such as bulk density, tapped density, compressibility index, Hausner’s ratio, and angle of repose. After conducting in vitro drug release experiments, all of the formulations were assessed for pH, hardness, friability, drug content and weight variation test. Conclusion: Formulation F12 was considered the best formulation and immediate the release up to 88.9% at 1min 10 sec. Higher concentrations of SSG may work well as a carriers to increase drug release and produce a tablet with immediate release.

Keywords: Brexpiprazole, Immediate Release, Schizophrenia, serotonin-dopamine activity modulator.