Abstract

SYNERGIZING LIPID-BASED NANOPARTICLES, MICROROBOTICS, AND PLANT-DERIVED AGENTS FOR PRECISION DRUG TARGETING

Sengar Ashutosh*, Priyanka Maheshkumar Kushwaha

Abstract

Targeted drug delivery systems are transforming contemporary therapy with more precision, efficacy, and safety. Recent developments for the past few years are discussed here with focus on lipid-based nanospheres, microrobotic platforms, and plant-derived molecules for more efficient, targeted therapeutic treatment. Liposomal and vesicular nanocarriers provide controlled release of the drug and biocompatibility with living systems, whereas structural innovations enhance stability and efficacy of the payload. Target-directed codeable by being polymer-based, lipid nanoparticles respond to biologic signals like pH and availability of enzymes. PEGylation and pHsensitive carriers increase tumor-targeted delivery coupled with decreased overall toxicity. Magnetic microrobots and microdevices offer a novel paradigm of active navigation and localization, especially deep within tissues. Effervescent tablets and proniosomal systems provide greater oral bioavailability and patient compliance, and incorporation of phytomedicinal drugs such as Tribulus terrestris demonstrates successful merging of traditional medicine and nanocarrier systems. Natural extracellular vesicles have been engineered as biocompatible nontoxic drug delivery systems based on their intrinsic properties and targeted delivery capability to cells selectively. Reproducibility, regulatory approval, and long-term safety still pose issues with translation even in this regard. The review presents an integrated view of these heterogeneous yet interconnected strategies, invoking the impetus of interdisciplinarity to create clinically

Keywords: applicable smart delivery systems. Synergistic application of lipid-based nanocarriers, microrobots, and phytochemicals is a landmark advance towards efficient, tailored, and minimally invasive drugs.