Abstract

"ORODISPERSIBLE TABLETS: A REVOLUTION IN ORAL MEDICINE"

*Sujay Yadav D. K., Dr. R. Yogananada, Chethan Patel DN, Varun Shankar, Pramod Sangam P

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Abstract

Orodispersible tablets (ODTs) represent a pivotal advancement in oral drug delivery, engineered to disintegrate within seconds in the buccal cavity and thereby enhance therapeutic efficacy and patient compliance. They provide distinct advantages for geriatric, pediatric, and dysphagic populations by bypassing swallowing difficulties and improving dosing accuracy. Sophisticated formulation strategies, including lyophilization, sublimation, spray drying, and effervescent systems, have been integrated with novel excipient technologies to optimize disintegration, palatability and bioavailability. Recent progress in nanocrystals, microencapsulation, and co-processed excipients further extends their potential in taste masking and drug stability. Nonetheless, critical challenges remain in balancing rapid disintegration with mechanical integrity, costeffectiveness and packaging robustness. This review encapsulates contemporary innovations, persisting limitations and the prospective evolution of ODTs as a transformative dosage form in modern pharmaceutics.

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