Abstract

SIGNALING MECHANISMS OF ISCHEMIA-REPERFUSION INJURY: AN OVERVIEW

Gurfateh Singh*, Nancy Dhadwal and S.L.Harikumar

Abstract

Myocardial ischemia is a condition in which heart tissue receives inadequate blood flow, followed by inadequate oxygen and nutrient supply. However, reperfusion of the previously ischemic myocardium is often followed by detrimental changes in myocardial tissues, known as ischemia-reperfusion injury. The cellular effect of ischemia, reactive oxygen species, janus kinase/signal transducer and activator of transduction, mitochondrial permeability transition pore, ATP and inflammatory cascade involves in pathophysiology of ischemia reperfusion injury. In this review, we discussed the basic signalling mechanisms involved in ischemia-reperfusion injury.

Keywords: Reperfusion, JAK-STAT, ATP, MPTP.