Abstract

REVIEW OF CO-PROCESSED SUPERDISINTEGRANTS IN FASTDISSOLVING TABLET FORMULATIONS

Komal Anturkar*, Samiksha Likhar, Chandralekha Ambedayre, Sadique Shahid,

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Abstract

The multifunctional excipients, which encompass co-processed excipients, enhance the formulation's additional functions. Based on the source various types of super disintegrants are available, these can be classified as synthetic, semisynthetic, natural, and co-processed. Co processed superdisintegrants are specialized multifunctional excipients combining agents like Mannitol, sodium starch glycolate (SSG), microcrystalline cellulose (MCC), croscarmellose sodium (CCS), and crospovidone (CP), silica, and other polymers have emerged as critical catalysts in formulating disintegrating oral tablets. By combining swelling, wicking, compaction strength, and powder flow in a single particle system, these excipients surpass conventional physical mixtures and individual disintegrants in performance. In the development of pharmaceutical formulations, co-processed superdisintegrants have become a significant additive, providing answers to problems related to poor solubility, bioavailability, and patient compliance. The principles, mechanisms, and advantages of co-processed excipients, as well as the manufacturing procedure and uses of co-processed superdisintegrants in drug delivery systems, are thoroughly examined in this review article.

Keywords: Co-processed super-disintegrants, fast dissolving tablets, orally disintegrating tablets, Direct compression, pharmaceutical excipients, tablet disintegration.