Abstract

DEVELOPMENT AND CHARACTERIZATION OF NOVEL MICROSPONGE GEL LOADED WITH KETOPROFEN FOR TRANSDERMAL DELIVERY

Vinay H. S.*, Krishna K. R., Parthiban S.

.

Abstract

Aim: The study aimed to formulate and evaluate Ketoprofenloaded microsponge and microsponge gel systems for sustained topical delivery. Preformulation studies including melting point, solubility, and λmax confirmed drug purity, while FTIR indicated compatibility of Ketoprofen with ethyl cellulose, validating its suitability for controlled release. Methodology: Microsponges were prepared using ethyl cellulose and PVA in varying ratios and evaluated for particle size, drug content, entrapment efficiency, and in vitro release. All formulations showed >85% drug content and entrapment efficiency, with F6 showing the highest values (92.39% and 91.37%). In vitro studies confirmed sustained release up to 8 hours, with F6 showing the most controlled release (87.1%). Kinetic analysis revealed Zero-order release and Super Case II transport. Result: Optimized microsponges were incorporated into gels showing smooth texture, stability, and pH 6.1–6.4. Viscosity (10,840–11,320 cps) and spreadability (6.50–7.02 cm) were within acceptable limits. In vitro drug release from gels showed prolonged release, with F6MG1 achieving 90.6% cumulative release following Zeroorder kinetics. Conclusion: Ketoprofen-loaded microsponge gels were stable and effective, providing sustained drug release and showing potential as a controlled-release topical formulation for enhanced therapeutic efficacy.

Keywords: Ketoprofen, Microsponge, Ethyl cellulose, PVA, Sustained release, Topical gel, Zero-order kinetics, Super Case II transport.