Abstract

FORMULATION AND INVITRO EVALUATION OF IMMEDIATE RELEASE TABLETS CONTAINING FEBUXOSTAT

CH. Saibabu*, Samanthula Nitheesha

.

Abstract

In the present research work Febuxostat Immediate Release Tablet were prepared by direct compression method using varying concentrations of Lycoat, Crospovidone & Croscarmellose sodium as disintegrants. The formulations prepared were evaluated for precompression& post compression parameters. Form the drug excipient compatibility studies we observe that there are no interactions between the pure drug (Febuxostat) and optimized formulation (Febuxostat+ excipients) which indicates there are no physical changes. Post compression parameters was found to be within the limits. Among the formulation prepared the tablet containing 12mg of CCS shows 98.13% of the drug release within 45 min & follows first order kinetics. The precompression parameters like bulk density, tapped density, Carr’s index and angle of repose were determined. All the formulations showed acceptable flow properties. The postcompression parameters like the hardness, thickness, friability and weight variation, disintegration time, disintegration time in oral cavity and Invitro release were carried out and the values were found to be within IP limits.

Keywords: Febuxostat, CCS, Lycoat, Crospovidone.