Abstract

PATHOGENESIS OF THROMBOSIS: AN OVERVIEW

*John Ayodele Olaniyi

Abstract

The hemostatic process is a host defense mechanism that preserves the integrity of the closed, high-pressure circulatory system. This process must be rapid. When the process is activated, it remains critical in containing thrombus formation so that it is localized to the site of injury and modulates thrombus size to be proportionate to the injury. Thus, there is a balance between the pathways that initiate thrombus formation and the pathways that regulate or modulate thrombus formation. Physiologically, following vascular injury, a series of delicate, balanced, and dynamic reactions must take place to secure a stable blood clot. This is a preparatory process of normal wound healing to maintain normal circulation.

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