Abstract

CARBOXYMETHYLCELLULOSE -G - ACRYLAMIDE BLEND CHITOSAN MICROSPHERES FOR CONTROL RELEASE OF CHLORO PHENIRAMINE MALIATE

Dr.P.RamaKrishna*

Abstract

Semi-interpenetrating polymer network [IPN] microspheres of carboxy methyl cellulose-grafted-acryl amide/Chitosan microspheres were prepared by water-in-oil (W/O) emulsion method. These microspheres were loaded with, Chloro pheniramine maliate and Cross-linked with glutaraldehyde(GA); these microspheres were characterized by differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and laser particle size analyzer. DSC thermograms of Chloro pheniramine maliate.-loaded AAm-CMC/ Chitosan microspheres confirmed the molecular level distribution of Chloro pheniramine maliate in the polymer matrix. SEM of the microspheres suggested the formation of spherical particles. Swelling experiments on the microspheres provided important information on drug diffusion properties. Release data have been analyzed using an empirical equation to understand the nature of transport of drug containing solution through the polymeric matrices. The controlled release characteristic of the matrices for Chloro pheniramine maliate was investigated in pH 7.4 media. Particle size and size distribution of the microspheres was studied by laser light diffraction particle size analyzer. Drug was released in a controlled manner up to 12 h.

Keywords: Carboxy methyl cellulose (CMC), Acryl amide (AAm), Chitosan (CS), Groft polymer, Semi-interpenetrating polymer network [IPN], cross linking, Chloro pheniramine maliate (CPM),controlled release etc.