Abstract

A REVIEW ON: SOLID LIPID NANOPARTICLES

*Samruddhi Kajulkar, Chetana Chaudhari, Prof. G. K. Brahma, Rohini Dargude, Shraddha Godage

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Abstract

The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could be used for secondary and tertiary levels of drug targeting. Hence, solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence have attracted wide attention of researchers. Solid lipid nanoparticles are one of the developed technologies for addressing the bioavailability and targeting issues of drug delivery. In this review article, we attempted to incorporate all the essential details of SLNs like method of preparation, lipids use in SLNs advantages and disadvantage. Solid lipid nanoparticles (SLNs) are made from lipids that are safe for the body. These nanoparticles have been shown to help drugs dissolve better, be taken up by cells more effectively, and stay stable for longer. They also protect drugs from being broken down by enzymes and help them stay in the bloodstream for a more extended period. SLNs have been carried out within the oral, parenteral, transdermal, intranasal, ocular, and pulmonary drug delivery of various drugs, with more suitable safety, bioavailability, and normal healing outcomes.

Keywords: solid lipid nanoparticles, bioavailability, hydrophilic, bioactive, lipophilic, biotoxicity, homogenization, biocompatible.