Abstract

PHYTOCHEMICAL INVESTIGATION AND ANTI-INFLAMMATORY ACTIVITY OF AN ISOLATED FRACTION OF STEROLS FROM THE FRUIT EXTRACT OF CARISSA CARANDUS

Preeti Bhadauria*, Akanksha Kulshreshtha and Vandna Sikarwar

Abstract

sterols fraction from methanolic extract of the fruits of carissa carandus was investigated for anti-inflammatory activity in animal models.The powder of carissa carandus fruits was subjected to extraction with methanol in soxhlet extractor. The methanolic extract after preliminary phytochemical investigation showed the presence of sterols, triterpenoids, phenolic compounds and flavonoids. Results of the study revealed that sterols possesses significant anti-inflammatory activity. The anti-inflammatory activity was studied using acetic acid induced vascular permeability and croton oil induced ear edema at a two different doses (200 and 400 mg/kg) of methanolic extract. The methanolic extract of carissa carandus fruit was exhibited significant anti-inflammatory activity at the dose of 400 mg/kg in both models when compared with control group. Indomethacin (10 mg/kg) was also shown significant anti-inflammatory activity in both models.

Keywords: Carissa carandus, Phytochemical investigation, Anti-inflammatory activity, Sterols, Methanolic extracts