Abstract

“A COMPARATIVE ANTICANCER ACTIVITY OF PLUMBAGO ZEYLANICA COLLECTED FROM NORTHERN AND SOUTHERN PARTS OF INDIA”

Dr. Rajesh Sharma*, Dr. Shraddha Naik, Dr. Vikas Saroch and Dr. Gousia Chasoo

Abstract

Cancer is one among the largest cause of deaths worldwide. Increasing interest and research on herbal medicine have revealed its importance in treating many diseases including cancer. The present study was carried out to evaluate the invitro anticancer activity of root extracts of Plumbago zeylanica Linn. Collected from two different geographical areas of India i.e. Himalayas (Jammu region) and Western Ghats (Belgaum region) against five different cancer cell lines. To determine the anticancer activity Alcoholic, Hydroalcholic and Aqueous extracts of Plumbago Zeylanica are prepared and anti-cancer activity is performed using Sulphorodamine B assay (SRB). Hydroalcholic extracts showed significant growth inhibition of HCT-15 cell line i.e. Colon cancer cells at all concentrations as compared to alcoholic and aqueous extracts and Aqueous extracts inhibits the growth of MCF-7 Breast cancer cells at 50,70 and 100 μg/ml concentrations. Comparison of IC50 values and linearity of the activity, it is observed that the sample of Northern region (Jammu) has promising results as compared to the sample collected from the Southern region.

Keywords: Cancer, Geographical areas, Plumbago zeylanica, various extracts, anticancer activity, Sulphorodamine B assay.