Abstract

DEVELOPMENT AND CHARACTERIZATION OF TRANSDERMAL PATCH OF ONDANSETRON MICROSPONGE TO TREAT CHEMOTHERAPY INDUCED NAUSEA AND VOMITING

Vamshi Pradeep N.*, Sudha B. S., Shachindra L. Nargund

Abstract

The present study aims to develop ondansetron microsponge loaded transdermal patch for the management of Chemotherapy-induced nausea vomiting (CINV). Method and results: Microsponges were prepared by using the quasiemulsion solvent diffusion method, optimized the formulations by selecting suitable retardant material (Ethyl cellulose and Eudragit L 100), type of internal phase, volume of internal and external phase, concentration of surfactants and process variables such as stirring conditions like speed and time. F10 showed the highest entrapment efficiency (94.99%) and 95.12% in vitro drug release. This optimized formulation was further incorporation into a patch base, Optimized Microsponge loaded transdermal patch (M-LTP) was compared with Ondansetron loaded transdermal patch (O-LTP). The M-LTP showed highest drug release compared to O-LTP and M-LTP demonstrated a consistent and sustained drug release over 11 hours. The stability studies demonstrated that the prepared microsponge (F10) And M-LTP has good stability after one months, with no considerable changes. Conclusion: The optimized microsponges showed the desired drug release profiles and physical characteristics. M-LTP of ondansetron can be a promising system for the transdermal for effective treatment for chemotherapy induced nausea vomiting (CINV).

Keywords: Ondansetron, Microsponges, Quasi emulsion solvent diffusion, Ethyl cellulose, Eudragit L 100, O-LTP, M-LTP.