Abstract

SINGLE USAGE OF CERASURGE PRO DELIVERS 72- HOUR HYDRATION WITH BARRIER SUPPORT: A 72- HOUR RANDOMIZED, CONTROLLED STUDY ON DRY SKIN VOLUNTEERS

Dr. Geetanjali Shetty, Rushabh Dharamshi, Poorna Pai, Drashti Shah, Kartiki

Abstract

Ceramides are vital lipid molecules necessary for preserving skin texture, moisture and barrier integrity in both males and females, keeping skin robust, smooth, and healthy. Fundamental role of ceramides in maintaining stratum corneum structure and function is universal across both genders, as biological mechanisms of skin barrier, physiology do not differ significantly between males and females. Lipid lamellae architecture and ceramide-dependent barrier repair processes operate identically regardless of gender, making ceramidebased interventions equally relevant and beneficial for all individuals. The body wash containing CeraSurge Pro, with a 5-ceramide complex, represents a novel approach to skin cleansing as a functional cleanser that actively restores skin barrier and moisture balance while removing impurities. Unlike conventional surfactant-based washes that may deplete essential lipids, this ceramide rich formulation deposits biomimetic lipid layers on the skin, offering measurable hydration and barrier support even after rinsing. This study, evaluated safety and efficacy of the ceramide-based body wash in enhancing skin moisturization and barrier function compared to untreated control in 33 healthy Indian females (aged 18-40) with dry forearm skin. Single application to designated forearm site was assessed over 72 hours using subject self-evaluation, dermatological evaluation, tewametry (transepidermal water loss, TEWL), and corneometry (skin hydration). Results demonstrated statistically significant improvements in skin hydration with increased moisture levels and reduced TEWL, indicating enhanced barrier function. Subject self-evaluation reported high user satisfaction with improved skin softness and comfort. No adverse effects were observed confirming formulation safety. These findings suggest that body wash containing CeraSurge Pro is a promising intervention for dry skin.

Keywords: Skin hydration; TEWL; Barrier repair; Ceramides; Body wash; Long-lasting moisturization.