Abstract

BIOLOGICAL APPROACH OF MAGNESIUM OXIDE NANOPARTICLES SYNTHESIZE BY SPIRULINA PLATENSIS

Mohammad Irfan Ali*, Gaurav Sharma, Manoj Kumar, Nakuleshwar Dut Jasuja,
Rajgovind

Abstract

Background-The present study explores extracellular synthesis of magnesium oxide nanoparticles (MgO NPs) using the aqueous extract of Spirulina platensis. Biosynthesized MgO NPs were characterized by UV-Vis spectroscopy, XRD and FTIR studies and finally tested for antibacterial activity. Methods- Biosynthesis using extract of S. platensis showed the formation of well scattered, highly stable, spherical MgO NPs with an average size of 30-40 nm. The size and morphology of the nanoparticles were confirmed by SEM and TEM analysis. Results- Furthermore, the synthesized nanoparticles exhibited good antibacterial activity against pathogenic gram-negative i.e. Escherichia Coli- MTCC-9721, Proteus vulgaris- MTCC-7299, Klebsiella pneumonia- MTCC-9751 and gram-positive i.e. Staphylococcus aureus- MTCC- 9542, S. epidermidis- MTCC- 2639, Bacillus cereus- MTCC-9017 bacteria. The MgO NPs had shown maximum zone of inhibition (ZOI) i.e. 25.3±0.48 in S. aureus- MTCC-9542. Conclusion- Use of such a biological method provides a simple, cost-effective alternative model for the synthesis of nanomaterials in a large scale that could be exploit in biomedical applications.

Keywords: Magnesium oxide nanoparticles, Spirulina platensis, Antibacterial activity, and Biosynthesis.