Abstract

RESTORATIVE EFFECT OF CURCUMA LONGA ON ESTROGEN AND UTERUS OF CHLORPYRIFOS EXPOSED MICE

Abstract

Pesticides are considered a vital component of modern farming. They are used to control organisms that are considered to be harmful. They are also used in grocery stores and food storage facilities to manage rodents and insects that infest food such as grain. Now a day’s preterm birth, spontaneous abortion and miscarriages are very common problem. In this experiment bioremedial effect of Curcuma longa on uterus and estrogen level of chloropyrifos induced mice were studied in detailed. The control group of mice received distilled water as drinking water. The ‘treatment’ groups received Chlorpyrifos 6 mg/kg b.w daily by Gavage method for two, four and eight weeks followed by four and eight weeks administration of alcoholic extract of root of Curcuma longa (50 mg/kg/b.w/day). Animals were sacrificed after the scheduled treatment. Chloropyrifos causes increase in estrogen level. Degenerated endometrium and muscular layer was observed. Frequent vacuolization was observed in stroma layer. While Curcuma longa causes restoration in estrogen level. Endometrial layer and endometrial gland were restored to greater extent. Muscular layer was almost normal like. Thus it is concluded from entire study that Curcuma longa restores uterus effectively and decreases chances of miscarriage, preterm birth and spontaneous abortions.

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