Abstract

ANTIOXIDANT EFFICACY OF SESBANIA GRANDIFLORA LINN IN ALLOXAN INDUCED WISTAR ALBINO RATS

Ruth Christiya.C, Dr. J. Radhika* and Jothi. G

Abstract

Generation of free radicals during metabolism and other activities beyond the antioxidant capacity of a biological system results in oxidative stress, leading to cancer, heart disease, neurodegenerative disease etc. Plants have been an essential part of human life since the Vedic era. Recently there is an upsurge of interest in the therapeutic potential of medicinal plants as antioxidants in reducing free radical induced tissue damage. The present study was designed to analyse the antioxidant efficacy of Sesbania grandiflora Linn in alloxan induced albino rats. Animals were grouped into six and each group consist of six rats each. Group I- normal rats(Control) , Group II- Alloxan induced rats, Group III - Alloxan induced + plant extract(500 mg/kg b.wt) treated rats, Group IV- Alloxan induced + plant extract(750mg/kg b.wt) treated rats, Group V- Alloxan induced + glibenclamide treated rats and Group VI - plant extract (750 mg/kg b.wt) treated rats. Animals were screened for the parameters such as Total protein, LPO and antioxidant enzyme levels. Alloxan induced group showed a marked decrease in the level of total protein and antioxidant status and also a marked elevation of LPO. The plant extract administered orally to the alloxan induced rats for 45 days, produced significant decrease in the level of LPO and also produced marked increase in total protein level and antioxidant enzymes such as GR, GPx, SOD, and CAT which was comparable to glibenclamide treated rats. The above results clearly depicts that aqueous extract of Sesbania grandiflora Linn possesses significant antioxidant property.

Keywords: Oxidative stress, antioxidant, Glutathione reductase, Glutathione peroxidase.