Abstract

RANDOMIZED CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY OF JWARAHARA MAHAKASHAYA AS GUDAVARTI IN JWARASANTAPA W.S.R TO PYREXIA IN CHILDREN

*Dr. Deepthi P. (B.A.M.S M.D), Dr. Divyasri R. A. (BAMS MD), Dr. Sudheer B. R (BAMS MD)

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Abstract

Introduction: Fever in children accounts for 70% of presenting complaints in the pediatric practices. Even though fever has some benefits like, stimulating the body's defense mechanism, it can also lead to medical complications in young children. In treating the cases of fever, palatability of Jwarahara Dravyas has been one of the prime reasons for the lesser proliferation of Ayurvedic drugs in pediatric age group. The efficacy of Jwarahara drugs administered orally is well known, however when administered parenterally specifically through rectal route was less tested, which presently is the need for the day. Hence, this study aims to evaluate the efficacy of Jwarahara Mahakashaya as Gudavarti, in the management of Jwarasantapa (Pyrexia) in children. Methods: 30 subjects(2- 5years) who were diagnosed with Jwarasantapa (Pyrexia) were randomly selected. They were divided into two groups of 15 subjects each. Group A was administered with Jwarahara Mahakashaya Gudavarti and Group B was administered with Amrutottara Kashaya Gudavarti. Assessment was done at regular interval ie. before treatment, 30 minutes, 60 minutes,120minutes & 180 minutes after the administration of Gudavarti, based on the subjective and objective parameters and graded accordingly. Observations & Results: Both medicines were found to be effective within the groups with highly significant P value. On comparing the efficacy of treatment between the group, Jwarahara Mahakashya Gudavarti showed better results in Jwarasantapa. Discussion: Jwarahara Mahakashaya Gudavarti and Amrutottara Kashaya Gudavarti with its potential Doshahara(alleviation of Doshas) action along with various phytochemical properties showed significant reduction of Jwarasantapa (pyrexia) in both the groups. Jwarahara Mahakashaya Gudavarti had sustained action on Jwarasantapa up to 180 minutes of treatment. Conclusion: The efficacy of Jwarahara Mahakashaya Gudavarti was greater than that of Amrutottara Kashaya Gudavarti in Jwarasantapa w.s.r to pyrexia in children.

Keywords: Jwarasantapa; Pyrexia in children; Gudavarti; Jwarahara Mahakashaya Gudavarti; Amrutottara Kashaya Gudavarti.