Abstract

PHARMACOVIGILANCE-BASED REVIEW OF CETIRIZINE ADVERSE REACTIONS: A CLINICAL PHARMACY LEARNING PERSPECTIVE

Alugu Alpha, Kotipalli Vijaya Sri Ganga Bhavani, Saladi Baby Rani, Meesala Kavya Kusuma, Geddam Sanjana, Geddam Ratna Priya, Devanaboyina Narendra, D. Veerandra Kumar*

Abstract

This review examines cetirizine, a commonly prescribed second-generation H₁-receptor blocker used for allergic conditions, focusing on adverse drug reactions (ADRs) relevant to pharmacy practice. While cetirizine is generally welltolerated, emerging data reveal important safety concerns beyond typical side effects. This teaching resource integrates current pharmacovigilance data, case examples, and practical guidance to help pharmacy students and clinical practitioners understand cetirizine safety comprehensively. The article covers ADR classification systems, risk identification, patient monitoring, and management strategies. Special emphasis is placed on central nervous system effects, post-discontinuation pruritus (a newly recognised phenomenon), cardiac manifestations, and hepatotoxicity. The review demonstrates how clinical pharmacists can actively detect, evaluate, and report ADRs, contributing meaningfully to patient safety in both institutional and community pharmacy settings. Through structured case discussions and mechanism-based learning, this resource prepares future practitioners to recognise ADR patterns and implement evidence-based monitoring protocols.

Keywords: Cetirizine, antihistamines, adverse drug reactions, pharmacovigilance, pharmacy education, clinical practice, drug safety.