Abstract

A COMPREHENSIVE REVIEW ON SODIUM ALGINATE BEADS FOR PEPTIC ULCER MANAGEMENT

Sanjana S.*, Ramya D., Shree G., Fathima Jamsheena N., Varshitha D., Shivubairegowda U. N.

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Abstract

Peptic ulcer disease (PUD) is a prevalent gastrointestinal disorder characterized by mucosal injury due to excessive gastric acid and pepsin secretion. Affecting approximately 10% of the global population, PUD is a chronic condition with significant morbidity. Helicobacter pylori (H. pylori) infection and nonsteroidal anti-inflammatory drugs (NSAIDs) are the primary causes of PUD. However, eradicating H. pylori infections poses significant challenges, including poor drug accessibility and short gastric residence times. Sodium alginate beads have emerged as a promising drug delivery system, offering regulated release and improved bioavailability. This review provides a comprehensive overview of recent advancements in sodium alginate bead formulation and evaluation methodologies. The integration of innovative formulation strategies and precise evaluation techniques has significantly enhanced the performance and functionality of sodium alginate beads, paving the way for their diverse applications in drug delivery and tissue engineering.

Keywords: Peptic Ulcer, Helicobacter pylori, Sodium Alginate Beads.