Abstract

REVIEW ON: ROLE ON NATURAL PRODUCT IN NEUROPROTECTION

Mr. Mayur Uday Dongare*, Miss. Mayuri Anil Kalaskar, Miss. Radha Manohar

Abstract

Natural products—plant-derived phytochemicals, marine metabolites, and dietary components—have attracted substantial interest as potential neuroprotective agents. This review synthesizes current knowledge on the mechanisms by which natural compounds confer neuroprotection, summarizes key preclinical and clinical evidence for representative molecules (polyphenols, flavonoids, alkaloids, terpenoids, fatty acids, and cannabinoids), discusses formulation and translational challenges (bioavailability, blood–brain barrier permeability, standardization), and proposes directions for future research. Emphasis is placed on mechanistic categories (antioxidant, anti-inflammatory, anti-apoptotic, mitochondrial stabilization, autophagy modulation, and synaptic protection) and on strategies to advance promising compounds toward clinical application.

Keywords: neuroprotection, natural products, phytochemicals, polyphenols, blood–brain barrier, neurodegeneration, antioxidant, inflammation.