Abstract

FORMULATION AND EVALUATION OF TELMISARTAN AND METOPROLOL SUCCINATE EXTENDED RELEASE TABLET

S. Hariharan*, A. Chandra, Dr. M. Senthilraja

Abstract

Hypertension management frequently necessitates combination therapy, and a fixed-dose combination (FDC) OF Telmisartan (an angiotensin II Receptor Blocker) and metoprolol succinate (a selective Beta Blocker) offers synergistic control over blood pressure. Current multi-tablet regimens often lead to poor patient compilance. The aim of this study was to develop and evaluate a single, once-Daily extended-release (ER) FDC tablet to simplify the regimen, enhance patient adherence, and maintain steady, therapeutic plasma concentrations over 24 hours. The methods of formulation strategy involved creating a dual-release system, combining immediate/modified release telmisartan with extended-release metoprolol succinate into a bilayer or matrix tablet. The tablets were prepared using wet granulation a method chosen to optimize blend uniformity, flow and comprehensibility.

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