Abstract

FORMULATION AND EVALUATION OF ANTIEMETIC ONDANSETRON HYDROCHLORIDE ORAL THIN FILM

Jyoti H. Jankar*, Rucha V. Pandit*, Kalyani N. Shinde*, Hitakshi N. Keluskar*,

Abstract

Patient struggling to swallow traditional tablets or capsules could gain advantages from a medication delivery system that dissolves rapidly. The present research seeks to develop oral thin films of Ondansetron via the solvent casting technique. Ondansetron Hydrochloride is a 5-HT3 Receptor Antagonist used as an Anti-emetics, Serotonin Antagonists, Anti-anxiety Agents, Antipsychotics, Anti-pruritics agent with extensive first pass metabolism which results in less bioavailability. The fast releasing films were prepared using polymers such as HPMC E5, HPMC E15, PVA, PVP K 30, as either single polymer or in a combination of two, by solvent casting technique with the help of polyethylene glycol as a plasticizer and aspartame as a sweetening agent. The drug releasing 98.40% within 60 sec as compared to other formulations as well as conventional tablets. This review article discusses the benefits of oral dispersible films compared to other oral dosage forms, particularly oral dispersible tablets, as well as their various applications.

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