Abstract

OPHTHALMIC NANOEMULSIONS: INVESTIGATING COMPOSITION, TECHNOLOGICALPROCESSES, AND QUALITY MANAGEMENT

Dr. Rupali R. Tasgaonkar, Pallavi Bangar, Utkarsha Sangle*

Abstract

Nanoemulsions designed for ocular drug delivery present significant potential in pharmaceutical applications, attributed to their transparency at increased droplet volume fractions, enhanced bioavailability rates, and extended shelf life. These formulations are components of multiphase colloidal dispersions, characterized by a heterogeneous system that includes fine oil-in-water or water-in-oil dispersions, along with surfactants and co-surfactants, containing droplets within a size range of 20–600 nm, exhibiting a narrow size distribution. This review outlines the preparation, characteristics, evaluation, and application of nanoemulsions as a means for drug delivery in ocular treatments. It provides a comprehensive summary of the development of ophthalmic nanoemulsions that facilitate sustained release and prolonged therapeutic effects. The review discusses various methods, including both high-energy and low-energy techniques, in detail. Lastly, it briefly addresses the techniques for characterization, in-vivo evaluation, and applications.

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