Abstract

SYNTHETIC AND PHARMACOLOGICAL EVALUATION OF SOME 3- (4-{[(SUBSTITUTEDPHENYL) METHYLENE] AMINO} PHENYL)-6- BROMO-2-METHYL QUINAZOLIN-4-ONE DERIVATIVES

Ravindra Kumar*, R.K. Shukla, Abha Shukla and Neelam Tyagi

Abstract

A series of ten novel compounds (3a) 3-(4-{[(2-chlorophenyl) methylene] amino}phenyl)-6-bromo-2-methylquinazolin-4-one; (3b) 3-(4-{[(4-chlorophenyl) methylene] amino} phenyl)-6-bromo-2- methylquinazolin-4-one; (3c) 3-(4-{[(3,4-dimethoxyphenyl) methylene] amino} phenyl)-6-bromo-2-methylquinazolin-4-one; (3d) 3-(4-{[(phenylmethylene] amino}phenyl)-6-bromo-2- hylquinazolin-4- one; (3e) 3-(4-{[(2-ydroxyphenyl) methylene] amino} phenyl)-6- bromo-2-methylquinazolin-4-one; (3f) 3-(4-{[(4-hydroxy-3- methoxyphenyl) methylene] amino} phenyl)-6-bromo-2 methylquinazolin-4-one; (3g) 3-(4-{[(4-hydroxyphenyl)methylene] amino} phenyl)-6-bromo-2-methylquinazolin-4-one; (3h) 3-[4-{[(4- (dimethylamino) phenyl) methylene] amino) phenyl]-6-bromo-2- methylquinazolin-4-one; (3i) 3-(4-{[(4-methoxyphenyl) methylene] amino} phenyl)-6- bromo-2-methylquinazolin-4-one ; (3j) 3-(4-{[(3-nitrophenyl) methylene] amino} phenyl)-6- bromo-2-methylquinazolin-4-one (3a -3j) have been synthesized by the reaction between 3- (4-aminophenyl)-6-bromo-2-methylquinazolin-4-one and different substituted aldehydes by using ethanol as a solvent. The newly synthesized compounds were characterized by elemental, IR and mass spectra analysis. The synthesized compounds were evaluated for antibacterial and antifungal activities by Agar diffusion method. All the compounds (3a-3j) were screened for their antibacterial activity against E. coli, S. aureus, B. spizinzenii, P. aeruginosa, S. paratyphi, B. pumillus, K. pneumoniae, and yeast C. albicans by disk diffusion method. Compounds showed good antibacterial activity against Staphylococcus aureus and Bacillus spizinzenii. Compounds 3a -3j exhibited good antifungal activity against Candida albicans fungus.

Keywords: 4-Quinazolinone, 4-Benzoxazinone, Synthesized & Characterized, antibacterial, antifungal.