Abstract

FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF CYNODON DACTYLON ROOT EXTRACT FOR IT’S ANTICOAGULANT ACTIVITY

Nitesh Devvanshi*, Kakli Rai*, Azad Chauhan*, Anjana Singh*, Ashirvad Chauhan*, Ankit Chauhan

Abstract

Cynodon dactylon, a tropical grass has been traditionally used in folk medicine to treat various ailments. The present study aimed to extract the root part of Cynodon dactylon and evaluate the anticoagulant activity. The extract was prepared by using maceration method with aqueous & non aqueous solvent and evaluation of it’s anticoagulant activity by using blood clotting time measurement method. The extract was subjected to preliminary photochemical screening which gives the confirmation of presence of active metabolite like phenolic compound, alkaloid, flavonoid etc. The result showed that the root extract of Cynodon dactylon exhibited significant anticoagulant activity. The study suggests that the root extract of Cynodon dactylon may be a potential natural anticoagulant agent. This study explores the development and evaluation of a transdermal patch containing Cynodon dactylon extract for anticoagulant activity. This may offer a novel approach for preventing and treating thrombotic disorders. This may provide a convenient and effective delivery system for Cynodon dactylon’s anticoagulant compounds.

Keywords: Anticoagulant, Cynodon dactylon, PBS, Patch, Folding endurance, etc.