Abstract

ROLE OF PROBIOTICS IN SYNBIOTIC MICROENCAPSULATION SYSTEMS FOR ENHANCED STABILITY AND TARGETED DELIVERY

Hemapriya N.*, Balaji R., Dr. RM. Akila

Abstract

Synbiotic microencapsulation combines probiotics with prebiotics in protective matrices to enhance microbial survival and functionality. Probiotics are highly sensitive to environmental and gastrointestinal stresses—such as heat, acidity, bile salts, and enzymatic activity—which reduce their viability and efficacy. Encapsulation using polymers like alginate, chitosan, starch derivatives, whey proteins, and cellulose provides a protective microenvironment during processing, storage, and intestinal transit. Prebiotics such as inulin, Fructooligosaccharides, Galactooligosaccharides, and resistant starch stabilize the matrix and act as substrates to support probiotic growth and colonization. This synergy improves gut persistence, targeted release especially in the colon and sustained viability. Encapsulation techniques including ionic gelation, layer-by-layer coating, spray drying, extrusion, and hybrid nano–micro systems ensure structural integrity and scalability. Synbiotic microencapsulation is a robust platform for functional foods, nutraceuticals, and therapeutic products, offering improved stability, controlled release, bioavailability, and sitespecific delivery, making it a key technology for next-generation probiotic applications.

Keywords: Synbiotic microencapsulation, Probiotic delivery systems, Targeted intestinal delivery, Controlled release, Biopolymer encapsulation, Alginate microbeads, Chitosan coating, Prebiotic co-encapsulation, Probiotic stability, Gastrointestinal protection; Colo