Abstract

MRSA – A SUPERBUG

Surabhi Johari*, Mridujuna Gogoi, Annesha Chakraborty, Rupanjali B. Sharma, Kanwar Narain, N. C. Barua

Abstract

Staphylococcus aureus is a gram-positive bacterium that is responsible for many hospital-associated infections as well as skin infections in humans and is characterized by its thick peptidoglycan cell wall layer common to gram-positive bacteria. Recent cases of infections caused by community-acquired methicillin-resistant Staphylococcus aureus (MRSA) (CA-MRSA) strains in healthy individuals have raised concerns worldwide. Several computer-aided drug design approaches like molecular docking studies and QSAR studies can be used in drug discovery in several ways. Molecular docking was carried out on Staphylococcus aureus with Dehydrosqualene synthase inhibitors. The present review reflects the alternative inhibitors designed for combating MRSA infections

Keywords: MRSA, QSAR, Docking, S.aureus.