Abstract

GOLD NANOPARTICLE: AS NOVEL CARRIER FOR DRUG DELIVERY

*Hemangi Shinde, Prfo K.R.Jadhav, Dr. A.Y. Pawar

Abstract

have successfully come to aid various disease states, but the advances in biomedical imaging depend largely on the shape, size, and selectivity of the nanoparticles to the target. Among nanoparticles, gold nanoparticles demonstrate special advantages in this field due to their unique properties, small size and high surface area-to-volume ratio. These particles have been widely used in various biomedical applications and drug delivery systems due to their inert nature, stability, high dispersity, non-cytotoxicity and biocompatibility. Gold nanoparticles are being used effectively in laboratory based clinical diagnostic methods while concurrently showing great promise in vivo either as a diagnostic imaging agent or a therapeutic agent.Gold Nanoparticles have appeared as an attractive candidate for various drug molecules or considered as extraordinary molecular carrier for the targeting including DNA, RNA, proteins, pepetides,drugs, genes and other molecules of therapeutic significance. This Review focuses on gold therapy and its biodistribution in humans, characteristics, types, synthesis methods, and functionaliztion of gold nanoparticles and its emerging applications various fields.

Keywords: Metallic nanoparticle, Gold nanoparticles, Surface plasmon resonance, Cancer imaging.