Abstract

SATELLITE DNA AS A BIOMARKER IN ORAL CANCER DETECTION

Dr. Shalini Gupta*, Dr. Yogendra Verma, Kumud Nigam, Shaista Suhail, Dr. O.P.Gupta

Abstract

Oral cancer has emerged as an increasing public health problem with high incidence and mortality rates all over the world. Therefore, the implementation of early detection of oral cancer approaches are importance which could reduce the morbidity and mortality rate. Sensitive and specific biomarkers for oral cancer are likely to be most effective for screening, diagnosis, staging and follow-up for this dreaded malignancy. Unlike other deep cancers, oral cancer is located in oral cavity. Hence, the oral cancer lesion makes the measurement of tumor markers in gene as an attractive alternative for tissue testing. The DNA molecules derived from the living cancer cells can be conveniently obtained from tissue. Thus DNA biomarkers, a noninvasive tissue-based biomarkers may be an effective modality for early diagnosis of disease, prognostication and monitoring post therapy status. The emerging field of DNA biomarkers has great potentials to prove its clinical significance to combat oral cancer. Hence, we have reviewed importance of DNA as biomarkers for oral cancer detection.

Keywords: screening, diagnosis, staging, prognostication and monitoring.