Abstract

CLINICAL ASSESSMENT OF SLEEP QUALITY AND COGNITION IN ALCOHOL DEPENDENCE AND WITHDRAWAL SYNDROMES - A COMPARATIVE OBSERVATIONAL STUDY

Dr. B. Manisha, M. Deepa, Y. M. Abdul Saleemoddin, Y. Sravani, D. Dilip*

Abstract

Background: Alcohol dependence syndrome (ADS) is a chronic disorder characterized by compulsive alcohol use, tolerance, and withdrawal. Long term alcohol consumption disrupts normal sleep patterns, leading to poor sleep quality, reduced sleep duration, and fragmented sleep. These disturbances negatively affect physical and mental health and may increase the risk of relapse. ADS is also associated with cognitive impairment, particularly in memory, attention, and executive functions, due to alcohols neuro toxic effects on the brain. These cognitive deficits can interfere with daily functioning and treatment outcomes. Understanding sleep quality and cognitive changes in ADS patients is essential for early identification and comprehensive management. Aim: To assess the sleep quality and cognitive impairment among patients diagnosed with alcohol dependence syndrome using standardized evaluation tools. Materials And Methods: A cross-sectional study was conducted over 6 months during the year 2025 to 2026 in the psychiatric department of Andhra Pradesh Vaidya vidya parishad hospital, Proddatur. A total number of 120 alcohol – attributed patients meeting the inclusion criteria were evaluated. Results: Overall 120 patients were included in the study. The demographic analysis revealed that 100 % of Male patients are consume Alcohol as a part in their daily life. The study is classified Alcohol induced diseases into two types : Alcohol Dependence Syndrome (ADS) [20% patients are Mild, 54% patients are Moderate, 42% patients are Severe] and Alcohol Withdrawal Syndrome (AWS) [33% patients are Mild, 33% patients are Moderate, 41% patients are Severe]; Alcohol induced Sleep Abnormality [0.83% patients have Good Sleep, 19.17% patients have Poor Sleep , 38.33 % patients have Moderate Sleep and 41.67% patients have Severe Sleep abnormality] and Cognitive Impairment [30.08% patients have Normal, 43.3 % patients have Mild, 24.39% patients have Moderate and 1.7% patients have Severe Cognitive Impairment] and Comparative Drug Therapy on Lorazepam [15%] and Chlordiazepoxide [40%] were frequently observed. Conclusion: Alcohol Dependence Syndrome (ADS) and Alcohol Withdrawal Syndrome (AWS) is strongly associated with significant Sleep disturbances and Cognitive impairment among affected patients. The study showed that most patients had moderate to severe ADS and AWS. A large proportion of patients experienced Moderate to Severe sleep abnormalities, indicating that chronic alcohol consumption disrupts normal sleep patterns. Cognitive assessment revealed that many patients had mild to moderate Cognitive impairment, affecting memory and attention. Chlordiazepoxide was more frequently used than lorazepam in the management of alcohol withdrawal symptoms.

Keywords: Alcohol Dependence Syndrome (ADS), Alcohol Withdrawal Syndrome (AWS), Sleep Impairment, Cognitive Impairment, Lorazepam, Chlordiazepoxide.