Abstract

A CONCISE REVIEW: NANOEMULSION-BASED DRUG DELIVERY SYSTEMS FOR TUBERCULOSIS THERAPY

Divanshu Bansal, *Lokesh Kumar Gautam

Abstract

The World Health Organization identifies tuberculosis (TB), caused by Mycobacterium tuberculosis, as a leading infectious killer. Although conventional treatments for TB exist, they come with challenges such as a heavy pill regimen, prolonged treatment duration, and a strict schedule, leading to multidrugresistant (MDR) and extensively drug-resistant (XDR) strains. The rise of MDR strains endangers future TB control. Despite these concerns, the hunt for an efficient treatment continues. Nanocarriers, such as nanoemulsion, lipid nanoparticles, nanosuspensions, liposomes, and polymeric micelles, facilitate targeted delivery of anti-TB drugs. The benefits of nanocarriers include reduced drug doses, fewer side effects, improved drug solubility, better bioavailability, and improved patient compliance, speeding up recovery. Additionally, nanocarriers can be made even more targeted by linking them with ligands such as mannose or hyaluronic acid. Nanoemulsions are colloidal dispersions having smaller globule size that ranges from 20-600 nm. Nanoemulsions are nano carrier drug delivery system for the protection of drugs from severe environmental conditions like pH, oxidation and hydrolysis. Nanoemulsions are normally contains oil phase, aqueous phase, surfactants and co-surfactants. Different methods are employed for the preparations of nanoemulsions are high pressure homogenization, microfluidization, ultrasonication, spontaneous emulsification, membrane emulsification, phase inversion temperature and solvent displacement method. Nanoemulsions are nano carrier system with safe and effective delivery of lipophilic and hydrophilic drug and also used in targeting.

Keywords: Tuberculosis, Mycobacterium tuberculosis, Nanoemulsion, Nanocarriers.