Abstract

HEPATOPROTECTIVE ACTIVITY OF ACHYRANTHES AGAINST JAUNDICE - A REVIEW

Shreya Rahele, *Ankita Undirwade, Dr. Mahendra Shiradkar

Abstract

Yellowing of the skin, eyes, or mouth might mean bilirubin levels are high in the blood. This shows up when the body handles bilirubin poorly - sometimes due to red blood cell breakdown, sometimes liver trouble, other times a bile pathway blockage. Depending on where things go wrong, it gets labeled before the liver, inside the liver, or after. Conventional methods used for these cases can bring unwanted reactions or fall short in results, so some turn toward plant-based alternatives instead. This research focuses on creating and evaluating a plant-based syrup meant to support liver function and address jaundice. Selection of species such as Achyranthes aspera, Phyllanthus niruri (Bhui amla), Ocimum sanctum (Tulsi), alongside Carica papaya leaves followed historical usage patterns combined with documented biological activities including oxidation control, inflammation reduction, virus suppression, and liver cell protection. From the plants came bits picked by hand, washed clean under running water. Dried slowly in shaded air, then crushed down until fine like dust. A machine called Soxhlet pulled out active parts using alcohol mixed with water - kept going for hours. After that, what was drawn out got concentrated, richer than before. Into a thick sweet base it went, where honey joined sucrose without fuss. Preserved with sodium benzoate so nothing spoiled too soon. Ascorbic acid slipped in to keep color bright. Polyethylene glycol helped everything stay smooth. Carboxymethyl cellulose gave body, just enough thickness. Citric acid brought a sharp note underneath. Peppermint oil finished it off with cool scent. A look at the mix showed things like acidity, thickness, how many microbes were present, also what it smelled and tasted like. This blend of herbs could work well as medicine that is gentle on the body, does not cost much, fits people easily - particularly kids and older adults. Working together, plant parts might help the liver do its job better while lowering bilirubin amounts. To back up these effects with proof, more lab tests plus real-world trials should happen next.

Keywords: Jaundice, Bilirubin, Hepatoprotective, Herbal syrup.