Abstract

METHANOL EXTRACT OF THE LEAVES OF ICHNOCARPUS FRUCTESCENS R. BR. (APOCYANACEAE) MODIFIES ANTIDIABETIC AND HYPOLIPIDEMIC CONDITION IN STREPTOZOTOCIN, TRITON AND HIGH FAT DIET INDUCED EXPERIMENTAL ANIMALS

V. Pushpa Rani*, A. Anitha Nancy, K. Shanmuga Priya, G. Meena Kumari, D.Arun Prasath

Abstract

The present study was designed to evaluate the effect of methanol extract of Ichnocarpus fructescens on the streptozotocin induced diabetic animals. The extract treated animals were failed to show significant reduction in plasma glucose level. However, the treatment had significantly reduced the plasma triglycerides and total cholesterol levels. Based on these results, another study was conducted to decipher the effect of methanol extract of I.fructescens on lipid metabolism. In this study, the plasma total cholesterol and triglyceride levels of I.fructescens methanol extract animals had shown a significant 47.17%, 66.36% and 78.27% reduction in triglyceride levels at 100, 200 and 400 mg/Kg respectively. The extract treatment with this extract also reduced the total cholesterol by 40.83%, 49.65% and 53.04% at 100, 200 and 400 mg/Kg respectively in triton (Tyloxapol) induced hyperlipidemic animals. Therefore , a long term study was conducted to determine the efficacy of the extract in High-fat induced obese animals. In this current study, the methanol extract treatment had shown a significant 13.69% reduction in triglyceride levels. In an acute toxicity study, the treatment with the methanol extract of I.fructescens, at the doses of 2 and 3g/Kg, the extract showed slight abdominal writhing. But the animals had recovered within 2hrs after treatment and there was no mortality. This indicates the less toxic effect of this extract. So, the fractionation of this extract will yield some novel prototypes to treat lipid related metabolic disorders.

Keywords: Ichnocarpus fructescens, hypolipidemic, antidiabetic, streptozotocin, Tyloxapol, HFD.