Abstract

EVALUATING A NOVEL PHYTO-THERAPEUTIC ANTI-BACTERIAL GEL

Patel Riddhiben Ashokkumar*, Chaudhari Archi Maneshkumar, Ms. Vaishali Pardhe

Abstract

This study focuses on the formulation and evaluation of a plantbased phyto-therapeutic antibacterial gel using an herbal drug delivery system. Herbal formulations have gained increasing attention because of their safety, biocompatibility, and reduced side effects compared to synthetic agents. Topical formulations are particularly important because they provide localized drug action, improve patient compliance, and minimize systemic exposure. The skin acts as a protective barrier; however, appropriate formulation strategies can enhance drug permeation across the stratum corneum. In this study, a phyto-therapeutic gel was developed using the ethanol extract of Calotropis gigantea flowers as the active pharmaceutical ingredient (API), known for its antimicrobial properties. The gel dosage form offers advantages such as ease of application, non-greasiness, and better patient acceptability. The formulation was evaluated for its antibacterial activity against common bacterial skin infections such as folliculitis, furuncle, and carbuncle, primarily caused by Staphylococcus aureus and Pseudomonas aeruginosa. Antimicrobial efficacy was assessed using the zone of inhibition method. The formulated gel exhibited a zone of inhibition measuring 12 mm against the gram- negative bacterium Pseudomonas aeruginosa and 20 mm against the gram-positive bacterium Staphylococcus aureus, indicating significant antibacterial activity. These results suggest that the developed phytotherapeutic gel is a promising topical formulation for the management of bacterial skin infections, combining the benefits of herbal medicine with effective drug delivery.

Keywords: Phytotherapeutic gel; Calotropis gigantea; Antibacterial activity; Carbopol 940; Topical drug delivery; Staphylococcus aureus; Pseudomonas aeruginosa.