Abstract

EXPLORING THE THERAPEUTIC POTENTIAL AND BIOACTIVE PROPERTIES OF URSOLIC ACID FROM ROSEMARY (ROSMARINUS OFFICINALIS): A COMPREHENSIVE REVIEW

Khadse Sahil Tukaram*, Wanole Amol Khanduji, Rai Shalini Dhirendra

Abstract

Ursolic acid (UA), a natural pentacyclic triterpenoid present in various plant sources, has attracted considerable interest due to its wide-ranging pharmacological effects, which include antiinflammatory, antioxidant, and anti-cancer properties. Although it is found in several plant species, Rosemary (Rosmarinus officinalis L.) stands out as a key and highly bioactive source of this compound.[1] This review consolidates findings from multiple scientific studies to assess the therapeutic potential of Ursolic acid derived from Rosemary for addressing complex medical issues. Existing research indicates that UA is crucial for metabolic health, as it promotes skeletal muscle growth and helps mitigate diet-related obesity and fatty liver disease.[2] In addition, its role in reproductive health, particularly in the management of Polycystic Ovary Syndrome (PCOS) through the regulation of insulin resistance, underscores its versatility.[3] The compound also demonstrates notable neuroprotective and cardiovascular advantages by influencing oxidative stress levels and enhancing endothelial function.[4] Moreover, its antibacterial and cytotoxic properties against several malignant cell lines position it as a promising candidate in the development of phytopharmaceuticals.[5][7] Despite its strong bioactivity, the clinical use of UA is often constrained by its low solubility in water and inadequate bioavailability, highlighting the need for further investigation into advanced delivery methods.

Keywords: Rosmarinus officinalis; Ursolic Acid; Pentacyclic Triterpenoid; Therapeutic Potential; Bioactive Properties; Phytochemicals.