Abstract

HYALURONIC ACID AS A MULTIFUNCTIONAL EXCIPIENT IN COSMECEUTICAL FORMULATIONS: ADVANCES AND FUTURE PERSPECTIVES

Onkar Satish Kokane*, Prachi Shantaram Dhonde, Ms. Kalyani Uttam Chande

Abstract

Hyaluronic acid have excellent biocampatability so it is widely used in cosmeceutical formulations and also it is naturally occurring glycosaminoglycan .This reduces the scope for ratcheting up demand on Cosmeceuticals, making them a focus, which capture both element: improving skin social health/ as well appearance.HA is essential for skin hydration, elasticity, and structural integrity which has made it one of the major ingredients in contemporary skincare. This review discusses the chemistry, physicochemical properties and multifunctional excipient role of HA in topical formulations. The skin penetration, hydration potential and biological activity of HA is greatly affected by its behavior depending on the molecular weight. It is also discussed in the context of anti-aging, as well as skin repair and regeneration. Recent studies have shown that newer techniques are being used for drug delivery, including liposomes, hydrogels, microneedles and nanoencapsulation systems which improve the delivery route as well as stability and efficacy of HA containing products. Novel trends like hybrid formulations, personalized skincare and sensor-based systems are massively changing cosmeceuticals in the future as well. Moreover, HA has been proven to be safe with low toxicity and high tolerability in topical and injectable therapies. So, the conclusion is that hyaluronic acid shows a versatile & trusted biomolecule in the cosmeceuticals industry, because of continuous discoveries its performance, stability, and therapeutic potential in advanced skincare applications will be improved.

Keywords: Hyaluronic acid; skin hydration; Anti-aging formulations; Transdermal delivery; Nanocarrier systems; Microneedle technology; Skin regeneration, cosmeceuticals.