Abstract

FORMULATION AND EVALUATION OF ALOE VERA BASED LEVOFLOXACIN GEL FOR THE TREATMENT OF PERIODANTAL DISEASES

Navya H. K.*, Mallikarjun Hindinmani, Abhishek C. Pasarad, Ramya M. Talawar, Vinayak M. Baligar, Aishwarya L. Shetter

Abstract

Background: Levofloxacin is a novel fourth generation fluoroquinolone with a broad spectrum of antibacterial activity against Gram-positive and Gram- negative anaerobic and aerobic periodontal pathogens. Dental uses of Aloe vera are multiple. It is extremely useful in the treatment of gum diseases like gingivitis, periodontitis. So in the present study, Objective: An attempt was be made to investigate the effect synergistic Aloe vera and Levofloxacin for the treatment of periodontal disease. Methods: The Aloe vera gels for levofloxacin with HPMC and Carbapol polymers were formulated and evaluated, Aloe vera Based levofloxacin gel were prepared at concentration of Carbapol polymers 200mg, 300mg, 400mg with HPMC polymers 400mg, 500mg, 600mg. Methyl parabin and Propyleparabin (0.002%) as preservative, sodium meta bisulphate acts as antioxidant and disinfectant, Triethonalamine acts as pH adjusting agent. All the prepared aloe vera gel formulations were evaluated for percentage yield, Drug content, Measurement of viscosity, pH determination, Syringeability. Results: FT-IR and DSC studies revealed that drug was found to be compatible with formulation excipients. All the formulations showed satisfactory results for pH, rheology and other physical properties. In-vitro release study revealed that release of drug from Aloe-vera gel was concentration dependent; as concentration of polymer increased the drug release rate was retarded. Based on maximum desirability and effectiveness formulation containing 200mg of carbapol polymer and 600mg HPMC polymer was consider as an optimized formulation. Conclusion: The Aloe-vera based levofloxacin gel is a promising approach for the treatment of periodontitis. This gel combines the advantage of an anti-inflammatory and antimicrobial activity.

Keywords: Levofloxacin, Aloe-vera gel, Carbopol, HPMC, periodontitis.